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KMID : 0390320210310020011
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Chungbuk Medical Journal
2021 Volume.31 No. 2 p.11 ~ p.18
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Urinary phthalate metabolite concentrations in residents near Cheongju industrial complex
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Lee Ji-Yong
Jung Woo-Chul
Park Jong-Uk
Lee Seo-In
Kim Yong-Dae
Kim Heon
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Abstract
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Purpose: Phthalates, which are well-known endocrine disruptors, represent a common type of air pollutant
emitted from industrial complexes. Few studies have reported phthalate exposure among residents in areas
near industrial complexes in Korea. In this study, we investigated the urinary phthalate metabolite
concentrations in residents of areas near the Cheongju National Industrial Complex and compared these values with those observed in the control area.
Materials and Methods: As part of the results of the “Second Stage of Environmental Pollution Exposure and Health Impact Monitoring in the Cheongju industrial complex (2012?2015)”, the total number of subjects included 4,190 residents of the industrial complex (within 3 km) and residents included in the control (comparison) group (areas extending over ≥7 km). Data regarding demographic characteristics, residence, and alcohol consumption/smoking habits were obtained via direct interview. Using high performance liquid chromatography/mass spectroscopy, we analyzed five varieties of phthalate metabolites in spot urine samples. Statistical analysis was performed using the SPSS software, version 25.0, and p<0.05 was considered statistically significant.
Results: After adjustment for age and sex, we observed that the urinary concentrations of the phthalates investigated in this study (mono-n-butyl phthalate, mono 2-ethyl-5-oxohexyl phthalate, mono 2-ethyl-5-hydroxyhexyl phthalate, mono-benzyl phthalate, and mono-2-ethyl-5-carboxypentyl phthalate) were significantly higher in residents near industrial complexes than in the control group. Linear regression analysis showed that residence near an industrial complex was significantly associated with concentrations of all five phthalate metabolites measured in this study.
Conclusion: This study highlights that urinary phthalate metabolite concentrations are higher in residents near the Cheongju industrial complex than in those residing in non-industrial complexes. Active prevention programs and education are warranted to prevent phthalate exposure among residents of areas near industrial complexes.
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KEYWORD
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Industrial complex, phthalate metabolites, general population
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